Memory Enhancement Using
Closed-Loop Neuromodulation

Memory impairment is one of the most devastating symptoms and one of the major comorbidities in a wide spectrum of neurological and psychiatric disorders such as Alzheimer’s disease, epilepsy, sleep disorders, stroke, PTSD, depression, and schizophrenia. Several studies have shown that direct stimulation of the brain enhances memory in rodents and humans by modulating the neuronal activities. The memory-enhancing effect of direct brain stimulation is associated with specific patterns of neural activities that can represent a biomarker of memory function. We design intelligent neuromodulation systems to investigate the causal link between modulating the neurophysiological biomarkers of memory and the subsequent behavioral outcome.